LBG - FS2024 – Exercise 2

Author

Peter von Rohr

Problem 1: Single Locus Genotypic Values

Use the dataset with genotypes of a single locus G and with phenotypic observations of a quantitative trait (y) to get estimates of the parameters \(a\) and \(d\) used for genotypic values for locus G. The dataset is available at:

https://charlotte-ngs.github.io/lbgfs2024/data/geno_val_single_loc.csv

  • Filter homozygous genotypes from dataset
  • Fit regression model on homozygous genotypes
  • The parameter \(a\) is the mean of the absolute values of the estimates for Intercept and for the regression slope.
  • The estimate for parameter \(d\) is the mean if the heterozygous genotypes corrected for the sum of the intercept and the slope.